Xceptional Instruments

Three-Tec AG

18 mm High-Containment System

Integrated gravimetric dosing, twin-screw extrusion, conveying, and granulation inside an ISO 14644-7 glove-box enclosure — powder to finished granulate without a clean room.

cGMPISO 14644-7316L
Three-Tec 18 mm high-containment glove-box extrusion system with integrated dosing, extruder, conveyor, and granulator

01 / 04OVERVIEW

The 18 mm High-Containment System encloses the entire process chain — gravimetric dosing, twin-screw extrusion, conveyor cooling, and strand granulation — inside an ISO 14644-7 compliant glove-box housing. Operators handle material through integrated glove ports; all drives sit external to the enclosure to eliminate particulate contamination from mechanical components. Every product-contact surface is 316L stainless steel (1.4404). The system processes potent compounds, cytotoxic APIs, and controlled substances that would otherwise require dedicated clean-room suites, reducing facility investment while maintaining containment integrity. Siemens PLC orchestrates the full line from a single HMI.

02 / 04FEATURES

Full process chain enclosed: dosing → extrusion → conveying → granulation
ISO 14644-7 glove-box containment — no dedicated clean room required
All drives external to the enclosure for zero particulate contamination
316L stainless (1.4404) on every product-contact surface
Glove-port handling for potent compounds and cytotoxic APIs
Single Siemens HMI controls the integrated line

03 / 04SPECIFICATIONS

Technical data

EXTRUSION
Screw diameter18 mm
Screw typeCo-rotating twin-screw
L/D ratioOn request
Max torqueOn request
Max pressureOn request
CONTAINMENT
StandardISO 14644-7
Enclosure typeGlove-box, integrated glove ports
Drive locationExternal to enclosure
INTEGRATED LINE
DosingGravimetric, integrated
ConveyorCooling conveyor, integrated
GranulationStrand granulator, integrated
CONTROL
PLCSiemens S7-1500
HMISingle-point control for full line
COMPLIANCE
Contact material316L stainless (1.4404)
StandardscGMP, ISO 14644-7
DIMENSIONS
FootprintOn request
Three-Tec 18 mm high-containment system, alternate view showing glove ports and external drive arrangement
Fig. 02Three-Tec 18 mm high-containment system, alternate view showing glove ports and external drive arrangement

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